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BIOE Seminar: Molecular Biomimicry by the SARS-CoV-2 Virus Dr. Gerard C. L. Wong Login information will be automatically distributed to current BIOE students, faculty, affiliates, and postdocs, as well as recipients of our weekly seminars email. If you do not currently receive our weekly seminars emails and would like to attend this event, please email Alyssa Tomlinson (awolice@umd.edu). Molecular biomimicry by the SARS-CoV-2 virus: consequences for severe inflammation, coagulation, and dysregulation of antiviral responses The two most salient features of COVID-19 are its high infectivity, and its lethality for a significant human subpopulation. The lethal pathologies include 1) amplified forms of inflammation (Acute Respiratory Distress Syndrome (ARDS), cytokine storms, septic shock) and 2) dysregulated forms of coagulation (severe blood clots that lead to cardiac events, multi system inflammatory syndrome in children (MIS-C)). At present, it is not clear how these outcomes are induced. By combining machine learning, synchrotron structural studies, computer simulations, in vitro cell based experiments, in vivo mouse experiments, and analysis of human COVID patient samples, we show how immune processing of SARS-CoV-2 can potentially precipitate these outcomes, via a novel form of biomimicry that results in grossly distorted immune responses, coagulation pathologies, and suppression of type I interferon-based antiviral defenses, whereas that of other non-pandemic coronaviruses cannot. About the Speaker
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