June 13, 2021 UMD Home FabLab AIMLab


The study will employ a specialized reactor to generate engineered nanoparticles in collaboration with the world's largest manufacturer of nanoparticles, who will also evaluate the particles for actual application as tire reinforcements and in conductive polymers. The studies will employ and develop state-of-the-art, real-time particle characterization methods, including quantitative single-particle mass spectrometry, as well as particle characterization that bridges the gap between the molecular and particulate scales. Process models that include detailed chemistry coupled to aerosol dynamics will be developed as a predictive tool to provide detailed information on both microstructure and composition. A particularly attractive feature of the project is its inclusion of an extensive effort in toxicology. Mechanisms of particle-cell interactions will be evaluated and potential adverse/beneficial effects will be determined using a tiered testing approach. At first, in vitro studies will be performed using specific target cells (lung epithelial, vascular endothelial, neurons and others) to evaluate the oxidative stress inducing potential of the engineered nanoparticles. This will be followed by in vivo studies in rats with delivery of the particles to the circulation and to the lung, followed by evaluation of potential adverse pulmonary and systemic effects. The proposed work combines an outstanding capability to manipulate and characterize nanoparticle structure, morphology, and chemistry with an industrial firm willing to evaluate their performance in multibillion-dollar applications, and a team of medical researchers performing fundamental studies on the degrees and mechanisms of their toxicity. As such, the study addresses current key issues concerning both the commercial and societal impacts of nanotechnology.

September 9, 2005


«Previous Story  

 

 

Current Headlines

Postdoc Candidate Sought at Naval Research Laboratory

Eric Wachsman Elected President of Electrochemical Society

UMD, UMBC, ARL Announce Cooperative Agreement to Accelerate AI, Autonomy in Complex Environments

Liangbing Hu Named 2021/2022 Distinguished Scholar-Teacher

'Fluorinated interphase' bolsters water-based zinc battery chemistry

Engineering at Maryland magazine celebrates 40 Years of the Center for Minorities in Science and Engineering

Engineering Undergrads Recognized for Excellence

Eric Marksz Awarded Charles A. Caramello Distinguished Thesis Award

Building Energy Innovation in Maryland

A Paradigm Shift in Nanochannel Research

 

Colleges A. James Clark School of Engineering
The College of Computer, Mathematical, and Natural Sciences

Communicate Join Email List
Contact Us
Follow us on TwitterTwitter logo

Links Privacy Policy
Sitemap
RSS

Copyright The University of Maryland University of Maryland
2004-2021